Transcendental wisdom has special anthropological foundations that were not paid enough attention to before Mulla Sadra. Sadra's philosophical opinions, as the main pillars of transcendental wisdom, are based on new foundations and unique to an individual who opens a different perspective to thinkers. According to Mulla Sadra's point of view, the relationship between science and practice is a one-sided relationship; In moving from practice to knowledge, practice has a preparatory and preliminary dignity, and in moving from science to practice, practice is the fruit of knowledge. This research has investigated the impact of Sadra's anthropological foundations on his analysis of the relationship between science and practice with an inferential method and a descriptive-analytical approach. These foundations are: the physicality of occurrence and the spirituality of the survival of the soul, the unity of science and the world and the known, the evolutionary movement and human strength, the unity of human identity despite the multiplicity of levels. By analyzing these foundations, an interpretation is presented in accordance with Sadra's anthropological view on the relationship between science and practice.